Signalling is the study of how information flows in biological systems, including how cells and organisms sense, integrate, and transmit information within themselves and with the external environment. Specifically, we are interested in the molecular and cellular aspects of signalling—the biochemical pathways that transduce information and the resulting downstream functional consequences.

We study the role of signalling in a variety of processes including:

  • Gene expression
  • RNA processing
  • Vesicle trafficking
  • Cytoskeletal dynamics
  • Secretion
  • Neuronal firing
  • Transmitter release

Our research takes place in an array of model systems, including mice, cultured eukaryotic and bacterial cells, and in vitro structural biology platforms. Although our work may seem diverse, it is unified by a common goal of understanding the mechanistic and functional effects of signalling in biological systems.