New Insights on the Impact of 2'-O-Methylation on Alternative RNA Conformational States

In Nucleic AcidResearch, Drs. Hala Abou Assi, Christopher Holley, Hashim Al-Hashimi and team unveil that 2'-O-methylation (Nm) preferentially stabilizes alternative secondary structures where Nm-modified nucleotides are paired, increasing the abundance and lifetime of low-populated short-lived excited states up to 10-fold. Read more