Richard Brennan (Chair)

James B. Duke Professor of Biochemistry
Chair, Department of Biochemistry
Brennan Lab, Primary Faculty
Research Interests: 

Gene Function and Regulation, Microbial Pathogenesis, Multidrug Resistance and Tolerance, Oxidative Stress, Protein Structure and Function, Protein-Nucleic Acid Interaction, Structural Biology, X-ray Crystallography

For the latest information on the Brennan Lab, please visit our website.

(919) 684-9471
Education

PhD University of Wisconsin at Madison, 1984

Publications
  1. Miao, Y, Tenor, JL, Toffaletti, DL, Liu, J, Shadrick, WR, Schumacher, MA, Lee, RE, Perfect, JR, and Brennan, RG.  Structures of trehalose-6-phosphate phosphatase from pathogenic fungi reveal the mechanisms of substrate recognition and catalysis.  Proc. Natl. Acad. Sci. U.S.A. 113:7148-7153 ( June 2016).
  2. Perfect, JR, Tenor, JL, Miao, Y, and Brennan, RG.  Trehalose pathway as an antifungal target.  Virulence 1:1-7 (June 2016).
  3. Cuthbert, BJ, Brennan, RG, and Schumacher, MA. "Structural and Biochemical Characterization of the Francisella tularensis Pathogenicity Regulator, Macrophage Locus Protein A (MglA)." PloS one 10, no. 6 (January 2015): e0128225-.
  4. Schumacher, MA, Balani, P, Min, J, Chinnam, NB, Hansen, S, Vulić, M, Lewis, K, and Brennan, RG. "HipBA-promoter structures reveal the basis of heritable multidrug tolerance." Nature 524, no. 7563 (August 2015): 59-64.
  5. Schindler, BD, Seo, SM, Birukou, I, Brennan, RG, and Kaatz, GW. "Mutations within the mepA operator affect binding of the MepR regulatory protein and its induction by MepA substrates in Staphylococcus aureus." Journal of bacteriology 197, no. 6 (March 2015): 1104-1114.  Full Text
  6. Reniere, ML, Whiteley, AT, Hamilton, KL, John, SM, Lauer, P, Brennan, RG, and Portnoy, DA."Glutathione activates virulence gene expression of an intracellular pathogen." Nature517, no. 7533 (January 2015): 170-173.  Full Text
  7. Kovach, AR, Hoff, KE, Canty, JT, Orans, J, and Brennan, RG. "Recognition of U-rich RNA by Hfq from the Gram-positive pathogen Listeria monocytogenes." RNA (New York, N.Y.) 20, no. 10 (October 2014): 1548-1559.  Full Text
  8. Tschowri, N, Schumacher, MA, Schlimpert, S, Chinnam, NB, Findlay, KC, Brennan, RG, and Buttner, MJ. "Tetrameric c-di-GMP mediates effective transcription factor dimerization to control Streptomyces development." Cell 158, no. 5 (August 2014): 1136-1147.  Full Text
  9. Birukou, I, Seo, SM, Schindler, BD, Kaatz, GW, and Brennan, RG. "Structural mechanism of transcription regulation of the Staphylococcus aureus multidrug efflux operon mepRA by the MarR family repressor MepR." Nucleic Acids Res 42, no. 4 (February 2014): 2774-2788.  Full Text  Link to Item