Huanghe Yang (Primary)

Assistant Professor of Biochemistry
Assistant Professor of Neurobiology
Yang Lab, Primary Faculty
Research Interests: 

Ion and Lipid Transport, Cell Signaling, Physiology, Neuroscience, Pharmacology, In Vivo Imaging

For the latest information on the Yang Lab, please visit our website.

Lab Location
Nanaline Duke, Room 151
(919) 684-1406 (Office) (919) 681-0175 (Lab)
Honors and Awards
  • NIH Director's New Innovator Award (DP2), NIH, 2017-2022
  • ​International Essential Tremor Foundation Research Award, 2017-2018
  • Duke Center for Thrombotic and Hemostatic Disorders Young Investigator Translational Research Award, 2016-2017
  • ZHANG Cunhao Award, Awarded by Chinese Academy of Sciences, 2002
  • First prize in the 2012 UCSF Postdoctoral Symposium, Awarded by UCSF, 2012
  • Pathway to Independence Award (K99/R00), Award by NIH/NINDS, 2014-2018
Education

PhD Washington University in St. Louis, Biomedical Engineering, 2008

Publications
  1. Yang, H. & Cui, J. “BK channels” in HANDBOOK OF ION CHANNELS, eds J. Zheng and C. Matthew (BocaRaton, FL:CRC). 227–240 (2015).
  2. Yang, H. & Jan, L. “TMEM16 membrane proteins in health and disease” in Ion Channels in Health and Disease, eds G. Pitt (Academic Press/Elsevier) (in press).
  3. Huang, X., He, Y., Dubuc, A.M., Hashizume, R., Zhang, W., Reimand, J., Yang, H., Wang, T., Stehbens, S.J., Younger, S., Barshow, S., Zhu, S., Cooper, M.K., Peacock, J., Ramaswamy, V., Garzia, L., Wu, X., Remke, M., Forester, C.M, Kim, C.C., Weiss, M.A., James, D., Shuman, M.A., Bader, G.D., Mueller, S., Taylor, M.D., Jan, Y.N. & Jan, L.Y. EAG2 potassium channel with evolutionarily conserved function as a brain tumor target, Nat. Neurosci. (2015) 18:1236-46.
  4. Yang, H., Zhang, G. & Cui, J. BK channels: multiple sensors, one activation gate. Front. Physiol. (2015) 6:1-16.
  5. Zhang, G., Yang, H., Liang, H., Yang, J., Shi, J., McFarland, K., Chen, Y., Cui, J. A charged residue in S4 regulates coupling among the activation gate, voltage, and Ca2+ sensors in BK channels. J Neurosci. (2014) 34:12280-8.
  6. Tien J, Peters C.J., Wong XM, Cheng T, Jan Y.N., Jan L.Y.*, Yang H.*, A comprehensive search for calcium binding sites critical for TMEM16A calcium-activated chloride channel activity. eLife, 3:e02772. (2014) (Co-corresponding author).
  7. Hong, T.T*., Yang, H.*, Zhang, S.S., Cho, H.C., Kalashnikova, M., Sun, B., Zhang, H., Bhargava, A., Grabe, M., Olgin, J., Gorelik, J., Marbán, E., Jan, L.Y., Shaw, R.M. Cardiac BIN1 folds T-tubule membrane, controlling ion flux and limiting arrhythmia, Nat. Med. 20: 624-32.(2014) (* equal contribution).
  8. Sun, X., Shi, J., Delaloye, K., Yang, X., Yang, H., Zhang, G., Cui, J. The interface between membrane-spanning and cytosolic domains in BK channels is involved in  subunits modulation of gating. J. Neurosci. 33:11253-11261. (2013).
  9. Yang, J., Yang, H., Sun, X., Delaloye, K., Yang, X, Moller, A., Shi, J., Cui, J. Interaction between residues in the Mg2+-binding site regulates BK channel activation. J. Gen. Physiol. 141:217-28. (2013).
  10. Yang, H.*, Kim, A.*, David, T., Palmer, D., Jin, T., Tien, J., Huang, F., Cheng, T., Coughlin, S. ., Jan, Y.N., and Jan, L.Y. TMEM16F forms a Ca2+-activated cation channel required for lipid scrambling in platelets during blood coagulation. Cell.  151:111-22. (2012). (* equal contribution).
  11. Huang, F., Zhang, H., Wu M., Yang, H., Kudo, M., Peters, CJ, Woodruff, P.G., Solberg, O.D., Donne, M.L., Huang, X., Sheppard, D., Fahy, J.V., Wolters, P.J., Hogan, B.L.M., Finkbeiner, W.E., Li, M., Jan, Y.N., Jan, L.Y., and Rock, J.R. TMEM16A-CaCC modulates mucin secretion and airway smooth muscle contraction. Proc. Natl. Acad. Sci. U S A. 109(40):16354-9. (2012).  
  12. Berg, J., Yang, H., and Jan, L.Y. Ca2+-activated Cl- channels at a glance. J. Cell Sci. 125, 1367-1371. (2012).
  13. Yang, J.*, Krishnamoorthy, G.*, Saxena, A.*, Zhang, G., Shi, J., Yang, H., Delaloye K., Sept D. & Cui J. An epilepsy/dyskinesia-associated mutation enhances BK channel activation by potentiating Ca2+ sensing. Neuron 66, 871-83 (2010).  
  14. Cui, J., Yang, H. & Lee, U. Molecular mechanisms of BK channel activation. Cell. Mol. Life Sci. 66, 852-75 (2009).
  15. Yang, H., Shi, J., Zhang, G., Yang, J. Delaloye, K. & Cui, J. Activation of Slo1 BK channels by Mg2+ coordinated between the voltage sensor and the RCK1 domains. Nat. Struct. Mol. Biol. 15, 1152-9 (2008).
  16. Yang, H.*, Zhang, G.*, Shi, J., Lee, U., Delaloye, K. & Cui, J. Subunit-specific Effect of the Voltage Sensor Domain on Ca2+ Sensitivity of BK Channels. Biophys. J. 94, 4678-87 (2008). (* equal contribution).
  17. Yang, H.*, Hu, L.*, Shi, J., Delaloye, K., Horrigan, F. T., & Cui, J. Mg2+ Mediates Interaction between the Voltage-Sensor and Cytosolic Domain to Activate BK channels. Proc. Natl. Acad. Sci. U S A. 104 18270-75 (2007). (* equal contribution).
  18. Yang, H.*, Hu, L.* B. S., Shi, J. & Cui, J. Tuning Magnesium Sensitivity of BK Channels by Mutations. Biophys. J. 91, 2892-900 (2006). (* equal contribution).
  19. Hu, L., Yang, H., Shi, J. & Cui, J. Effects of Multiple Metal Binding Sites on Calcium and Magnesium-dependent Activation of BK Channels. J. Gen. Physiol. 127, 35-50 (2006).
  20. Du, W.*, Bautista, J. F.*, Yang, H., Diez-Sampedro, A., You, S. A., Wang, L., Kotagal, P., Luders, H. O., Shi, J., Cui, J., Richerson, G. B. & Wang, Q. K. Calcium-sensitive potassium channelopathy in human epilepsy and paroxysmal movement disorder. Nat. Genet. 37, 733-8 (2005) (* equal contribution).