Huanghe Yang (Primary)

Assistant Professor of Biochemistry
Assistant Professor of Neurobiology
Member of the Ion Channel Research Unit, Cardiology
Yang Lab, Primary Faculty
Research Interests: 

Ion and Lipid Transport, Cell Signaling, Physiology, Neuroscience, Pharmacology, in vivo imaging
For the latest information on the Yang Lab, including news, publications, research and members, please see our group web site at

Lab Location
MSRB2, Room 2100E
(919) 684-1406 (Office) (919) 681-0175 (Lab)
Honors and Awards

ZHANG Cunhao Award, Awarded by Chinese Academy of Sciences, 2002
First prize in the 2012 UCSF Postdoctoral Symposium, Awarded by UCSF, 2012
Pathway to Independence Award (K99/R00), Award by NIH/NINDS, 2014-2018


Ph.D., Washington University in St. Louis, Biomedical Engineering, 2008


1.    Yang, H. & Cui, J. “BK channels” in HANDBOOK OF ION CHANNELS, eds J. Zheng and C. Matthew (BocaRaton, FL:CRC). 227–240 (2015).
2.    Yang, H. & Jan, L. “TMEM16 membrane proteins in health and disease” in Ion Channels in Health and Disease, eds G. Pitt (Academic Press/Elsevier) (in press).
3.    Huang, X., He, Y., Dubuc, A.M., Hashizume, R., Zhang, W., Reimand, J., Yang, H., Wang, T., Stehbens, S.J., Younger, S., Barshow, S., Zhu, S., Cooper, M.K., Peacock, J., Ramaswamy, V., Garzia, L., Wu, X., Remke, M., Forester, C.M, Kim, C.C., Weiss, M.A., James, D., Shuman, M.A., Bader, G.D., Mueller, S., Taylor, M.D., Jan, Y.N. & Jan, L.Y. EAG2 potassium channel with evolutionarily conserved function as a brain tumor target, Nat. Neurosci. (2015) 18:1236-46.
4.    Yang, H., Zhang, G. & Cui, J. BK channels: multiple sensors, one activation gate. Front. Physiol. (2015) 6:1-16.
5.    Zhang, G., Yang, H., Liang, H., Yang, J., Shi, J., McFarland, K., Chen, Y., Cui, J. A charged residue in S4 regulates coupling among the activation gate, voltage, and Ca2+ sensors in BK channels. J Neurosci. (2014) 34:12280-8.
6.    Tien J, Peters C.J., Wong XM, Cheng T, Jan Y.N., Jan L.Y.*, Yang H.*, A comprehensive search for calcium binding sites critical for TMEM16A calcium-activated chloride channel activity. eLife, 3:e02772. (2014) (Co-corresponding author).
7.    Hong, T.T*., Yang, H.*, Zhang, S.S., Cho, H.C., Kalashnikova, M., Sun, B., Zhang, H., Bhargava, A., Grabe, M., Olgin, J., Gorelik, J., Marbán, E., Jan, L.Y., Shaw, R.M. Cardiac BIN1 folds T-tubule membrane, controlling ion flux and limiting arrhythmia, Nat. Med. 20: 624-32.(2014) (* equal contribution).
8.    Sun, X., Shi, J., Delaloye, K., Yang, X., Yang, H., Zhang, G., Cui, J. The interface between membrane-spanning and cytosolic domains in BK channels is involved in  subunits modulation of gating. J. Neurosci. 33:11253-11261. (2013).
9.    Yang, J., Yang, H., Sun, X., Delaloye, K., Yang, X, Moller, A., Shi, J., Cui, J. Interaction between residues in the Mg2+-binding site regulates BK channel activation. J. Gen. Physiol. 141:217-28. (2013).
10.    Yang, H.*, Kim, A.*, David, T., Palmer, D., Jin, T., Tien, J., Huang, F., Cheng, T., Coughlin, S. ., Jan, Y.N., and Jan, L.Y. TMEM16F forms a Ca2+-activated cation channel required for lipid scrambling in platelets during blood coagulation. Cell.  151:111-22. (2012). (* equal contribution).
11.    Huang, F., Zhang, H., Wu M., Yang, H., Kudo, M., Peters, CJ, Woodruff, P.G., Solberg, O.D., Donne, M.L., Huang, X., Sheppard, D., Fahy, J.V., Wolters, P.J., Hogan, B.L.M., Finkbeiner, W.E., Li, M., Jan, Y.N., Jan, L.Y., and Rock, J.R. TMEM16A-CaCC modulates mucin secretion and airway smooth muscle contraction. Proc. Natl. Acad. Sci. U S A. 109(40):16354-9. (2012).  
12.    Berg, J., Yang, H., and Jan, L.Y. Ca2+-activated Cl- channels at a glance. J. Cell Sci. 125, 1367-1371. (2012).
13.    Yang, J.*, Krishnamoorthy, G.*, Saxena, A.*, Zhang, G., Shi, J., Yang, H., Delaloye K., Sept D. & Cui J. An epilepsy/dyskinesia-associated mutation enhances BK channel activation by potentiating Ca2+ sensing. Neuron 66, 871-83 (2010).  
14.    Cui, J., Yang, H. & Lee, U. Molecular mechanisms of BK channel activation. Cell. Mol. Life Sci. 66, 852-75 (2009).
15.    Yang, H., Shi, J., Zhang, G., Yang, J. Delaloye, K. & Cui, J. Activation of Slo1 BK channels by Mg2+ coordinated between the voltage sensor and the RCK1 domains. Nat. Struct. Mol. Biol. 15, 1152-9 (2008).
16.    Yang, H.*, Zhang, G.*, Shi, J., Lee, U., Delaloye, K. & Cui, J. Subunit-specific Effect of the Voltage Sensor Domain on Ca2+ Sensitivity of BK Channels. Biophys. J. 94, 4678-87 (2008). (* equal contribution).
17.    Yang, H.*, Hu, L.*, Shi, J., Delaloye, K., Horrigan, F. T., & Cui, J. Mg2+ Mediates Interaction between the Voltage-Sensor and Cytosolic Domain to Activate BK channels. Proc. Natl. Acad. Sci. U S A. 104 18270-75 (2007). (* equal contribution).
18.    Yang, H.*, Hu, L.* B. S., Shi, J. & Cui, J. Tuning Magnesium Sensitivity of BK Channels by Mutations. Biophys. J. 91, 2892-900 (2006). (* equal contribution).
19.    Hu, L., Yang, H., Shi, J. & Cui, J. Effects of Multiple Metal Binding Sites on Calcium and Magnesium-dependent Activation of BK Channels. J. Gen. Physiol. 127, 35-50 (2006).
20.    Du, W.*, Bautista, J. F.*, Yang, H., Diez-Sampedro, A., You, S. A., Wang, L., Kotagal, P., Luders, H. O., Shi, J., Cui, J., Richerson, G. B. & Wang, Q. K. Calcium-sensitive potassium channelopathy in human epilepsy and paroxysmal movement disorder. Nat. Genet. 37, 733-8 (2005) (* equal contribution).