Hashim M Al-Hashimi (Primary)

James B. Duke Professor of Biochemistry
James B. Duke Professor of Chemistry
Director, Duke Center for RNA Biology
Al-Hashimi Lab, Primary Faculty
Research Interests: 

The theoretical design and implementation of new NMR experiments for probing the physicochemical properties of biomolecules, with particular interest in RNA and DNA and the proteins and small molecules that bind to them.

For the latest information on the Al-Hashimi Lab, please visit our website

Lab Location
Nanaline Duke Room 227, Box 3711, 307 Research Dr, Durham NC 27710-3025
Tel: 919-660-1113 Lab Tel: 919-660-1114
Education

PhD Yale University, 2000

Publications
  1. Yang S. and Al-Hashimi H.M. (2015) "Unveiling Inherent Degeneracies in Determining Population-weighted Ensembles of Inter-domain Orientational Distributions Using NMR Residual Dipolar Couplings: Application to RNA Helix Junction Helix Motifs." J Phys Chem BIn Press.
  2. Zhou H., Hintze B., Kimsey I.J. Sathyamoorthy B., Yang S., Richardson J., Al-Hashimi H.M. (2015). "New Insights into Hoogsteen Base Pairs in DNA Duplexes from a Structure-based Survey." Nucleic Acid Research 43(7):3420-33.
  3. Mustoe A., Liu X., Lin P., Al-Hashimi H.M., Fierke C., Brooks C. (2015) "A non-canonical secondary structure stabilizes mitochondrial tRNASer(UCN) by reducing the entropic cost of tertiary folding.J Am Chem Society 137(10):3592-9.
  4. Xue Y., Kellogg D., Kimsey I.J., Sathyamoorthy B., Stein Z., McBrairty M. (2015). "Characterizing RNA Excited States using NMR Relaxation Dispersion.Methods in Enzymology 558:39-73.
  5. Kimsey I.J., Petzold K., Sathyamoorthy B., Stein Z.W., and Al-Hashimi H.M. (2015). "Visualizing Transient Watson-Crick Like Mispairs in DNA and RNA Duplexes.Nature 519(7543):315-20.
  6. Mouzakis K., Dethoff E.A., Al-Hashimi H.M. (2015). "Dynamic motions of the HIV-1 frameshift site RNA." Biophys J 108(3):644-54.
  7. Enrico R., Salmon L., Fragai M., Parigi G., and Al-Hashimi H.M.  (2014).  “Insights into Domain-Domain Motions inProteins and RNA from Solution NMR.”  Acc Chem Res 47(10):3118-26.
  8. Sathyamoorthy B., Lee J., Kimsey I.J., Ganser L., Al-Hashimi H.M. (2014).  “Development and Application of Aromatic[13C, 1H] SOFAST-HMQC NMR Experiment for Nucleic Acids.”  Biomolecular NMR 60(2-3):77-83. 
  9. Ganser L.R., Mustoe A.M., Al-Hashimi H.M.  (2014).  “An RNA tertiary switch by modifying how helices are tethered.”  Genome Biology15:425.
  10. Alvey H.S., Nikolova E.N., Gottardo F.L., and Al-Hashimi H.M. (2014). “Widespread Transient Hoogsteen Base-Pairs in Canonical Duplex DNA with Variable Energetics.”  Nat Commun 4(5):4786.