Dennis James Thiele (Secondary)

George Barth Geller Professor, Pharmacology & Cancer Biology
Professor of Biochemistry
Professor of Molecular Genetics & Microbiology
Thiele Lab, Secondary Faculty
Research Interests: 

Copper transporters in growth, development and disease; Communication between copper import and copper stores; Fe deficiency: reprogramming via mRNA degradation; Copper and iron in fungal pathogenesis; Heat Shock Factors in protein mis-folding diseases

Lab Location
LSRC Building
Office Location

LSRC Room C351, Duke Box 3813, Durham, NC 27710

(919) 684-5776

All organisms are exposed to stressful conditions including elevated temperatures, reactive oxygen species and other metabolites generated by normal biochemical reactions, rapid cellular proliferation, infection, inflammation, pharmacological agents or other pathophysiological states. These stressful conditions can lead to protein misfolding and aggregation, disruption of cellular signaling pathways, cellular dysfunction and cell death. Recent studies strongly suggest that the ability to sense and respond to stress signals, through the activation of signal transduction pathways, transcription factors and gene products that function in protein homeostasis is critical for normal growth, development and in the protection against diseases that include cancer, cardiovascular disease and protein folding diseases such as Alzheimer’s, Huntington’s and prion based disease. Furthermore, studies in model systems have established a strong correlation between longevity and the ability to mount robust stress responses for healthy immune systems, normal nutrient sensing and metabolism, protection from infectious disease and the prevention of cardiovascular disease. 

Education

PhD Rutgers University, 1983