Dennis James Thiele (Secondary)
Copper transporters in growth, development and disease; Communication between copper import and copper stores; Fe deficiency: reprogramming via mRNA degradation; Copper and iron in fungal pathogenesis; Heat Shock Factors in protein mis-folding diseases.
For more information on the Thiele Lab, please visit our website.
LSRC Room C351, Duke Box 3813, Durham, NC 27710
All organisms are exposed to stressful conditions including elevated temperatures, reactive oxygen species and other metabolites generated by normal biochemical reactions, rapid cellular proliferation, infection, inflammation, pharmacological agents or other pathophysiological states. These stressful conditions can lead to protein misfolding and aggregation, disruption of cellular signaling pathways, cellular dysfunction and cell death. Recent studies strongly suggest that the ability to sense and respond to stress signals, through the activation of signal transduction pathways, transcription factors and gene products that function in protein homeostasis is critical for normal growth, development and in the protection against diseases that include cancer, cardiovascular disease and protein folding diseases such as Alzheimer’s, Huntington’s and prion based disease. Furthermore, studies in model systems have established a strong correlation between longevity and the ability to mount robust stress responses for healthy immune systems, normal nutrient sensing and metabolism, protection from infectious disease and the prevention of cardiovascular disease.
- Metal Homeostasis in Yeast awarded by National Institutes of Health 1989 - 2018
- Copper Homeostasis in Mammals awarded by National Institutes of Health 2001 - 2016
- HSF1 as a therapeutic target in neurodegenerative disease awarded by National Institutes of Health2010 - 2016
- Targeting copper homeostasis in the fungal pathogen, Cryptococcus neoformans awarded by National Institutes of Health 2012 - 2014
- Molecular mechanisms of iron homeostasis in Saccharomyces cerevisiae awarded by National Institutes of Health 2008 - 2010
- Heat Shock Transcription Factor Function and Regulation awarded by National Institutes of Health1999 - 2009
- Stress regulation of RNA metabolism awarded by National Institutes of Health 2007 - 2008
- Mechanism by which a single transcription factor responds to multiple distinct stressors awarded by National Science Foundation 2005 - 2006
PhD Rutgers University, 1983