 Seok-Yong LeeAssistant ProfessorContact InformationTelephone: (919)-684-1005 Fax: (919) 613-5145 e-mail sylee@biochem.duke.edu Mailing Address Department of Biochemistry Duke University Medical Center Room 1015/MSRB II 106 Research Dr. Box 103030, DUMC Durham, NC 27710 Lab LocationRoom 1045Q Education
Research InterestsThe goal of our lab is to understand the molecular mechanism of integral membrane proteins responsible for ion transport across cell membranes. To do this, we use a multidisciplinary approach including X-ray crystallography, biophysics and electrophysiology. Selected Publications1. Seok-Yong Lee, James A. Letts, and Roderick MacKinnon, Functional reconstitution of purified human Hv1 H+ channels. J Mol Biol. 2009 Apr 17;387(5):1055-60. More… 2. Seok-Yong Lee, Anirban Banerjee, and Roderick MacKinnon, Two separate interfaces between the voltage sensor and pore are required for the function of voltage-dependent K+ channels. PLoS Biology 2009, 7(3): e47 More… 3. Seok-Yong Lee, James A. Letts, and Roderick MacKinnon, Dimeric subunit stoichiometry of the human voltage-dependent proton channel Hv1. Proc.Natl.Acad.Sci. 2008, 105(22):7692-5. More… 4. Seok-Yong Lee, Alice Lee, Jiayun Chen and Roderick MacKinnon, Structure of the KvAP voltage-dependent K+ channel and its dependence on the lipid membrane. Proc.Natl.Acad.Sci. 2005,102(43):15441-6. More… 5. Anne Roberts, Seok-Yong Lee, Emma McCullagh, Ruth E. Silversmith, and David E. Wemmer; Ybiv from Escherichia coli K12 is a HAD phosphatase. Proteins 2005, 58(4):790-801. More… 6. Seok-Yong Lee and Roderick MacKinnon; A membrane-access mechanism of ion channel inhibition by voltage sensor toxins from spider venom. Nature 2004, 430(6996):232-5 More… 7. Seok-Yong Lee, Armando de La Torre, Sydney Kustu, Tracy Nixon, David E. Wemmer; Regulation of the transcriptional activator NtrC1: Structural studies of AAA+ ATPase and regulatory domains. Genes Dev. 2003, 17, 2552-63. More… 8. Alexandra K. Gardino, Brian F. Volkman, Ho S. Cho, Seok-Yong Lee, David E. Wemmer, Dorothee Kern; The NMR Solution Structure of BeF3—Activated Spo0F Reveals the Conformational Switch in a Phosphorelay System. J.Mol. Biol. 2003, 331, 245-54. More… 9. Curt Hastings, Seok-Yong Lee, Ho S. Cho, Dalai Yan, Sydney Kustu, David E. Wemmer; High resolution solution structure of beryllofluoride-activated NtrC receiver domain. Biochemistry 2003, 42, 9081-90. More… 10. Seth M. Rubin, Seok-Yong Lee, Janette E. Ruiz, Alexander Pines, David E. Wemmer; Detection and characterization of xenon binding sites in protein by 129Xe NMR spectroscopy. J.Mol. Biol. 2002, 322, 425-40. More… 11. Seok-Yong Lee, Ho S. Cho, Jeffrey G. Pelton, Edward A. Berry, David E. Wemmer; Crystal structure of activated CheY. J. Biol. Chem. 2001, 276, 16425-31. More… 12. Seok-Yong Lee, Ho S. Cho, Jeffrey G. Pelton, Dalai Yan, Robert K. Henderson, David S. King, Sydney Kustu, Edward A. Berry, David E. Wemmer; “Crystal structure of response regulator, CheY, bound to its target;” Nat. Struct. Biol. 2001, 8, 52-6. More… 13. Ho S. Cho, Seok-Yong Lee, Dalai Yan, Xiaou Pan, John S. Parkinson, Sydney Kustu, David E. Wemmer, Jeffrey G. Pelton; “NMR structure of activated CheY;” J.Mol.Biol. 2000, 297, 543-51. More… 14. Dalai Yan, Ho S. Cho, Curtis A. Hastings, Michele M. Igo, Seok-Yong Lee, Jeffrey G. Pelton, Valley Stewart, David E. Wemmer, Sydney Kustu; “Beryllofluoride mimics phosphorylation of NtrC and other bacteria response regulators;” Proc.Natl.Acad.Sci. 1999, 96,14789-14794. More… 15. Seok-Yong Lee, Jeong-Hoon Lee, Ho-Jin Chang, Jun-Myung Cho, Jin-Won Jung, Wontae Lee; “Solution structure of a sweet protein single-chain monellin determined by nuclear magnetic resonance and dynamical simulated annealing calculations;” Biochemistry 1999,38(8), 2340-6. More… |
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