 Lorena S. BeeseJames B. Duke Professor of BiochemistryContact InformationTelephone: (919) 681-5267 Fax: (919) 684-8885 e-mail lsb@biochem.duke.edu Mailing Address Department of Biochemistry 212 Nanaline H. Duke Box 3711, DUMC Durham, NC 27710 Lab LocationRoom 212 Education
Research InterestsStructure and mechanism of proteins and macromolecular assemblies central to maintaining genome stability and cellular signaling. Structure-based drug design. Lab MembersSelected Publications1. Warren JJ, Pohlhaus TJ, Changela A, Iyer RR, Modrich PL, Beese LS. (2007)”Structure of the human MutSalpha DNA lesion recognition complex.” Mol Cell. 2007 May 25;26(4):579-92. More… 2. Warren, J.J., Forsberg, L.J., & Beese, L.S. (2006) The structural basis for the mutagenicity of O6-methyl-guanine lesions. Proc Natl Acad Sci. Dec 26;103(52):19701-6. More… 3. Terry, K.L., Casey, P.J. & Beese, L.S. (2006) Conversion of protein farnesyltransferase to a geranylgeranyltransferase. Biochemistry 45(32):9746-55. More… 4. Lane, K.T. & Beese, L.S. (2006) Thematic review series: lipid posttranslational modifications. Structural biology of protein farnesyltransferase and geranylgeranyltransferase type I. Journal of Lipid Research 47(4):681-699. More… 5. Johnson, S.J. and Beese, L.S. (2004) Structures of mismatch replication errors observed in a DNA polymerase. Cell, Vol. 116, March 19, 803-816. More… 6. Hsu, G.W., Ober, M., Carell, T. and Beese, L.S. (2004) Error-prone replication of oxidatively damaged DNA by a high-fidelity DNA polymerase. Nature Sep 9;431(7005):217-21. Epub 2004 Aug 22. More… 7. S.J. Johnson, J.S. Taylor, and L.S. Beese (2003). Processive DNA synthesis observed in a polymerase crystal suggests a mechanism for the prevention of frameshift mutations. Proc Natl Acad Sci Apr 1;100(7):3895-3900. More… 8. J.S. Taylor, T.S. Reid, K.L. Terry, P.J. Casey, and L.S. Beese (2003). Structure of mammalian protein geranylgeranyltransferase type-1. EMBO J 22(22):5963-5974. More… 9. Long, SB, Casey, P., Beese, LS (2002) The reaction path of protein farnesyltransferase at atomic resolution. Nature Oct 10; 419(6907):645-50. More… 10. Long SB, Hancock PJ, Kral AM, Hellinga HW, Beese LS. (2001) The crystal structure of human protein farnesyltransferase reveals the basis for inhibition by CaaX tetrapeptides and their mimetics. Proc Natl Acad Sci U S A Nov 6;98(23):12948-53. More… 11. J. R. Kiefer, C. Mao, J. C. Braman and L. S. Beese (1998) “Visualizing DNA replication in a catalytically active Bacillus DNA polymerase crystal [see comments].” Nature 6664:304-7. More… 12. H. W. Park, S. R. Boduluri, J. F. Moomaw, P. J. Casey and L. S. Beese (1997) “Crystal structure of protein farnesyltransferase at 2.25 angstrom resolution see comments.” Science 5307:1800-4. More… |
|
