Lorena S. Beese

1. Warren, J.J., Forsberg, L.J., & Beese, L.S. (2006) The structural basis for the mutagenicity of O6-methyl-guanine lesions. Proc Natl Acad Sci. Dec 26;103(52):19701-6. More…

2. Terry, K.L., Casey, P.J. & Beese, L.S. (2006) Conversion of protein farnesyltransferase to a geranylgeranyltransferase. Biochemistry 45(32):9746-55. More…

3. Lane, K.T. & Beese, L.S. (2006) Thematic review series: lipid posttranslational modifications. Structural biology of protein farnesyltransferase and geranylgeranyltransferase type I. Journal of Lipid Research 47(4):681-699. More…

4. Cuneo, M.J., Changela, A., Warren, J.J., Beese, L.S. & Hellinga, H.W. (2006) The crystal structure of a thermophilic glucose binding protein reveals adaptations that interconvert mono and di-saccaride binding sites. J Mol Biol 362(2):259-70. More…

5. Hsu, G.W., Huang, X., Luneva, N.P., Geacintov, N.E. & Beese, L.S. (2005) Structure of a high fidelity DNA polymerase bound to a benzo[a]pyrene adduct that blocks replication. Journal of Biological Chemistry 280:3764-70. More…

6. Reid, T.S., Long, S. & Beese, L.S. (2004) Crystallographic analysis reveals that anti-cancer clinical candidate L-778,123 inhibits protein farnesyltransferase and geranylgeranyltransferase-I by different binding modes. Biochemistry Jul 20;43(28):9000-8. More…

7. Reid, T.S. & Beese, L. S. (2004) Crystal structures of the anti-cancer clinical candidates R115777 (Zarbestra®/tipifarnib) and BMS-214662 complexed with protein farnesyltransferase suggest mechanism of FTI selectivity. Biochemistry 43(22):6877-84. More…

8. Reid TS, Terry KL, Casey PJ, Beese LS. (2004) Crystallographic analysis of CaaX prenyltransferases complexed with substrates defines rules of protein substrate selectivity. J Mol Biol. Oct 15;343(2):417-33. More…

9. Johnson, S.J. and Beese, L.S. (2004) Structures of mismatch replication errors observed in a DNA polymerase. Cell, Vol. 116, March 19, 803-816. More…

10. Hsu, G.W., Ober, M., Carell, T. and Beese, L.S. (2004) Error-prone replication of oxidatively damaged DNA by a high-fidelity DNA polymerase. Nature Sep 9;431(7005):217-21. Epub 2004 Aug 22. More…

11. S.J. Johnson, J.S. Taylor, and L.S. Beese (2003). Processive DNA synthesis observed in a polymerase crystal suggests a mechanism for the prevention of frameshift mutations. Proc Natl Acad Sci Apr 1;100(7):3895-3900. More…

12. J.S. Taylor, T.S. Reid, K.L. Terry, P.J. Casey, and L.S. Beese (2003). Structure of mammalian protein geranylgeranyltransferase type-1. EMBO J 22(22):5963-5974. More…

13. Bell IM, et al. (2002) 3-Aminopyrrolidinone farnesyltransferase inhibitors: design of macrocyclic compounds with improved pharmacokinetics and excellent cell potency. J Med Chem. Jun 6;45(12):2388-409. More…

14. Long, SB, Casey, P., Beese, LS (2002) The reaction path of protein farnesyltransferase at atomic resolution. Nature Oct 10; 419(6907):645-50. More…

15. Long SB, Hancock PJ, Kral AM, Hellinga HW, Beese LS. (2001) The crystal structure of human protein farnesyltransferase reveals the basis for inhibition by CaaX tetrapeptides and their mimetics. Proc Natl Acad Sci U S A Nov 6;98(23):12948-53. More…

16. A.C. Rodriguez, H.W. Park, C. Mao, L.S. Beese. Crystal structure of a pol alpha family DNA polymerase from the hyperthermophilic archaeon Thermococcus sp. 9 degrees N-7. J Mol Biol. 2000 Jun 2;299(2):447-62. More…

17. J. R. Kiefer, C. Mao, J. C. Braman and L. S. Beese (1998) “Visualizing DNA replication in a catalytically active Bacillus DNA polymerase crystal [see comments].” Nature 6664:304-7. More…

18. H. W. Park, S. R. Boduluri, J. F. Moomaw, P. J. Casey and L. S. Beese (1997) “Crystal structure of protein farnesyltransferase at 2.25 angstrom resolution see comments.” Science 5307:1800-4. More…